ea0098c52 | Clinical – Surgery/Applied Pathology | NANETS2023
AghaAmiri Solmaz
, Estrella Jeannelyn S.
, Hurd Mark W.
, Hernandez Vargas Servando
, Ghosh Sukhen C.
, Azhdarinia Ali
, Ikoma Naruhiko
Background: Accurate intraoperative localization of primary and metastatic pancreatic neuroendocrine tumors (pNETs) is challenging, and molecularly driven fluorescence-guided surgery could significantly improve surgical outcomes with given the overexpression of somatostatin receptor subtype-2 (SSTR2). We developed an optimized SSTR2-targeted fluorescent agent, MMC(FNIR-Tag)-TOC, which expressed excellent targeting specificity and pharmacokinetics, as the lead compound for clin...